Support research that can contribute to the production of more effective antivenoms as well as provide cures for currently untreatable diseases!
Accompany me on my quest to unlock the mysteries that have been stored inside the head of one of the world’s most enigmatic creatures; the rattlesnake. Your support will allow you to join me on my adventures through both my photographic and video blog posts as I travel around the desert southwest collecting venom samples from the southwestern speckled rattlesnake. By contributing to this project you are supporting basic research which provides the foundation necessary to unlock its therapeutic powers.
The planets biodiversity has provided cures for many illnesses that affect mankind. Countless other cures are still waiting to be discovered! The dilemma is that a cure may only exist in a single population that may be restricted to a single mountain range or even canyon. As urban sprawl encroaches on more and more habitat we are losing local populations of flora and fauna at an alarming rate. Former Director-General of the World Health Oranization and former Prime Minister of Norway Dr. Gro Harlem Brundtland summarized it best “The library of life is burning and we do not even know the titles of the books.” Simply put, we are losing our resources before we even know they exist! Currently venom has provided mankind with drugs that treat everything from heart attacks, strokes and sickle cell anemia, to high blood pressure, diabetes, and chronic pain.
So why venom variation in the southwestern speckled rattlesnake?????
A better understanding of venom variation has economic as well as public health ramifications. Our continued urban sprawl pushes human activity farther into habitat that was previously almost unoccupied putting man directly in contact with the venomous denizens of the desert foothills. This presents a problem as antivenom may not effectively neutralize envenomations across the entire range of species.
The aim of this project is to investigate intraspecific venom variation in the speckled rattlesnake. A montane island species of the desert southwest that possesses venom that presents different clinical effects in bite victims from across its range that are likely associated with differences in the species proteome (10 dollar science word meaning the entire set of expressed proteins).
So how the heck am I going to accomplish this?
If funded, I will be able to purchase the equipment, such as a dryshipper, necessary to conduct this research as well as afford travel from northern Baja California northeast through Sonora, California, Arizona, and Nevada until I reach extreme southwestern Utah. In each of these areas I will be stopping in various mountain ranges where I will capture southwestern speckled rattlesnakes and collect venom and blood samples from them. These samples kept frozen in the dry shipper, which uses liquid nitrogen, to avoid being destroyed by the intense heat of many of my collection areas. Upon return to my university I will use lots of very expensive equipment such as high pressure liquid chromatography and mass spectrometry machines to analyze my samples.
What will my work produce?
This project will result in papers published in scientific journals, as well as talks and posters presented at international and regional scientific conferences. I will also document my journey around the desert southwest on my blog, keeping my supporters informed of my progress with the aid of video and photographic media. By financially supporting my research you are directly supporting the scientific community which has faced major cuts in funding through traditional sources lately. My initial work funded by YOUR contribution is the crucial first step in obtaining leads for proteins that have the potential to provide significant medicinal benefits.
What will I be using the funds for?
Funds will be used to pay for equipment (like a dry shipper), lab work (it costs a lot to use some machines) and travel to various mountain ranges throughout the desert southwest.
Check out my blog:http://travels4toxins.wordpress.com/